10th CAR-TCR Summit

We are excited to announce that we will be attending the CAR-TCR Summit. Listen to presentation by Aleš Štrancar and visit as at a booth.

Location: Boston, MA

Listen to our presentation:

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In Process Control, From pDNA and mRNA to LNP

Speaker: Aleš Štrancar, Managing Director, Sartorius BIA Separations
Time and Date: Thursday, September 25, 2025, at 11:45 a.m.
Track: Analytical Development

Presentation abstract:

• LNPs with multiple payloads are very sheer sensitive, therefore the TFF purification should be replaced with CIM monolith column chromatography deprived of shear forces.
• LNPs with multiple payloads are very heterogenous, chromatography approach is required to purify the LNP product.
• To enable the batch-to-batch product manufacturing consistency new analytical method to characterise the pDNA, mRNA and LNP should be used.