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Insights and updates from BIA Separations
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A Guide to Monolithic Column Channel Sizes
A guide to choosing the right channel size of monoliths for biomolecules: pDNA, mRNA, AAV, LVV, bacteriophages, LNP, proteins, and more
Read more →What’s Holding Back mRNA-LNP Therapeutics?
Solving challenges in the areas of purity, consistency, and monitoring technologies is crucial for the development of mRNA-LNP therapeutics.
Read more →How Acidic Denaturation Facilitates dsRNA Removal
How to remove double stranded RNA for safer mRNA therapeutics, without special equipment and preserving the target molecule
Read more →The Next Generation of Chromatography: Moving From Classic HPLC to Advanced Platforms
Advanced chromatography platforms enhance process development with integrated solutions beyond traditional HPLC systems.
Read more →Transforming pDNA Purification: Insights from Christy Franco on VGXI's Monolith Technology Integration
VGXI's Christy Franco explains how monolith technology boosted pDNA purification yields from <10% to 70% and solved scale-up challenges
Read more →Optimizing AAV Upstream Process: High-Throughput Sample Preparation for Mass Photometer Analytics
Get fast and precise analysis of crude AAV harvest samples, using high-throughput sample preparation method for mass photometry.
Read more →Key Differences Between CIM QA and CIM QA HR
Monoliths ensure that full capsids consistently elute at the same salt concentration across various scales, highlighting superior performance and reproducibility.
Read more →AAV Processing Made Simple: Your Guide to Empty and Full Separation Success
A simple guide to overcome AAV empty/full purification and analytics challenges while enhancing overall product quality.
Read more →Using Multi-Well Plates When You Have Limited Samples
How to use just a part of the well-plate with a vacuum manifold, positive pressure manifold or centrifuge without wasting your sample
Read more →The Story of Citric Acid and Non-Reproducibility in Empty/Full AAV Separation: What Could Go Wrong?
Citric ions cause binding competition and magnesium chelation. Small adjustments in your DSP lead to better result.
Read more →Optimizing AAV Processes: Strategies for Effective Purification and Analysis
This blog post addresses the challenges in AAV purification and analytics, highlighting the scientific approaches to enhance product quality
Read more →AAV8 Capture Purification: Comparing Ion-Exchange Monolith and Affinity Resin
Recent advancements in chromatography have significantly boosted AAV production yields. CIMmultus® SO3 monolithic column, a strong cation exchanger (CEX) for AAV capture purification, has shown a remarkable 30% increase in...
Read more →Monolith Chromatography
A Guide to Monolithic Column Channel Sizes
A guide to choosing the right channel size of monoliths for biomolecules: pDNA, mRNA, AAV, LVV, bacteriophages, LNP, proteins, and more
Read more →Transforming pDNA Purification: Insights from Christy Franco on VGXI's Monolith Technology Integration
VGXI's Christy Franco explains how monolith technology boosted pDNA purification yields from <10% to 70% and solved scale-up challenges
Read more →Using Multi-Well Plates When You Have Limited Samples
How to use just a part of the well-plate with a vacuum manifold, positive pressure manifold or centrifuge without wasting your sample
Read more →AAV8 Capture Purification: Comparing Ion-Exchange Monolith and Affinity Resin
Recent advancements in chromatography have significantly boosted AAV production yields. CIMmultus® SO3 monolithic column, a strong cation exchanger (CEX) for AAV capture purification, has shown a remarkable 30% increase in...
Read more →Plasmid Dna
Optimizing the Plasmid Production Process | Role of Analytics
As the market for gene therapies continues to grow, the need for high quality plasmid (pDNA) is increasing. Many companies are looking to insource pDNA production and purification – usually...
Read more →Scalable Alkaline Lysis for pDNA Production
Alkaline cell lysis is technologically challenging, especially when working with large volumes, thus it is important to keep precise control over different factors
Read more →Quick Start Methods for Plasmid DNA Isoform Monitoring
A quick guide to monitor and quantify pDNA isoforms during the process development and production for optimized mRNA or AAV manufacturing
Read more →Mrna
What’s Holding Back mRNA-LNP Therapeutics?
Solving challenges in the areas of purity, consistency, and monitoring technologies is crucial for the development of mRNA-LNP therapeutics.
Read more →How Acidic Denaturation Facilitates dsRNA Removal
How to remove double stranded RNA for safer mRNA therapeutics, without special equipment and preserving the target molecule
Read more →WACKER Biotech's mRNA Process Optimization: A Comprehensive Approach
With fast analytics WACKER Biotech minimized the development activities and achieved 100% linearized pDNA, improving mRNA production process
Read more →Expert Insights Blog: Navigating RNA Therapeutics and LNP Innovations with Dan Peer from Tel Aviv University
Discover how advanced analytical techniques are transforming RNA therapeutics, ensuring precision and efficacy in delivery systems. A New Era in RNA TherapeuticsThe mRNA and lipid nanoparticles (LNPs) field is rapidly...
Read more →Aav
Optimizing AAV Upstream Process: High-Throughput Sample Preparation for Mass Photometer Analytics
Get fast and precise analysis of crude AAV harvest samples, using high-throughput sample preparation method for mass photometry.
Read more →AAV Processing Made Simple: Your Guide to Empty and Full Separation Success
A simple guide to overcome AAV empty/full purification and analytics challenges while enhancing overall product quality.
Read more →The Story of Citric Acid and Non-Reproducibility in Empty/Full AAV Separation: What Could Go Wrong?
Citric ions cause binding competition and magnesium chelation. Small adjustments in your DSP lead to better result.
Read more →Optimizing AAV Processes: Strategies for Effective Purification and Analysis
This blog post addresses the challenges in AAV purification and analytics, highlighting the scientific approaches to enhance product quality
Read more →