CRS 2025

Join our Workshop: Liquid Chromatography to Characterize and Purify your LNP Drug Product

Time and Date: Monday, July 14th from 8:00am to 12:00pm
Speakers:

• Tristan Kovačič, Project Manager, Sartorius BIA Separations
• Nejc Pavlin, Process Analytics Development Manager, Sartorius BIA Separations
• Mojca Tajnik Sbaizero, Process Development Manager, Sartorius BIA Separations

The participants will learn about the advantages of using chromatography to analyze and purify LNP drug
products. Specifically, the use cases on monolithic columns will be showcased. A PATfix chromatographic
system with an LNP analytical platform will be installed and presented and the use of hardware and
software demonstrated. Analytical methods will be shown that determine: RNA quantity and quality within
LNP drug products, encapsulation efficiency, size distribution, lipid composition, RNA-lipid adducts and
lipid quality. An alternative to existing purification methods for LNPs will be introduced.

Topics covered: 

• General discussion about LNP manufacturing/characterization challenges ( Tristan Kovačič and
  Nejc Pavlin)
• Chromatographic Analytics of LNP Drug Product (Nejc Pavlin)
• Chromatographic Purification of LNP Drug Product (Mojca Tajnik Sbaizero and Tristan Kovačič)
• PATfix Analytical Tool (Nejc Pavlin and Tristan Kovačič)

Explore our posters at CRS 2025:

• Monoliths for a novel selective and high recovering purification process of RNA-LNP pharmaceuticals, presented by Tristan Kovačič
• End-To-End Process for Improved Purity, Combined With Innovative Analytics of LNP-Based Therapeutics, presented by Mojca Tajnik Sbaizero

Join us at the booth #310

Location: Philadelphia, PA

Register Now!