RNA Leaders Europe Congress

Listen to our presentation

Speaker: Tomas Kostelec, Manager of Segment Technology, Sartorius
Time and Date: Wednesday, March 5, 2025 | 5:20 PM
Title: Advancing mRNA Therapeutics With Better Control Over mRNA Manufacturing Yield, Quality, and Formulation.

Abstract:

Adoption of RNA as a vaccine and therapeutic modality highlights the need for robust, cost-effective production and improved targeted delivery. Here, we present a rapid and efficient manufacturing process that combined with in-process analytics enable achieving IVT yields up to 25 g of RNA per L and attaining 80-100 % of RNA recovery after purification. We further present how innovating mRNA-LNP formulation supported by in-process analytics can lead to the generation of mRNA LNPs that have expanded extrahepatic biodistribution, improved drug delivery and cellular targeting.

About the event

The RNA Leaders Congress gathers over 400 attendees and more than 85 speakers. The program includes scientific tracks that delve into development strategies, trends, and technologies across the entire spectrum of long and small RNA. RNA Leaders propels the future of RNA development by connecting the most innovative companies with the right partners.

Location: Basel, Switzerland