World Orphan Drug Congress Europe 2025

Listen to our presentation

Speaker: Aleš Štrancar, Managing Director, Sartorius BIA Separations

Date and Time: Wednesday, October 29, 2025 at 1:45 PM (Track 5)

Title: Manufacturing of LNPs With Multiple Nucleic Acids Payloads and Surface “Decoration”

Abstract:

• LNPs with multiple payloads and proteins on the surface are very heterogenous, chromatography approach is required to purify the product.
• Replacing the TFF with OH chromatography improves the product recovery.
• To define the product and to enable the batch-to-batch product manufacturing consistency new analytical methods to characterise the LNP were developed.

About the event

The World Orphan Drug Congress is the largest and most established orphan drug & rare disease meeting of its kind across the globe. From cell and gene therapy, genetic testing, and market access, to real world evidence, this one meeting covers the whole orphan drugs value chain where science, government and manufacturers all come together to create ground breaking progress.

Location: Amsterdam, Netherlands

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