Datasheet | PATfix LNP Switcher Platform
The PATfix® LNP Switcher Platform is an innovative solution for LNP analysis in process development.
PATfix® LNP Switcher Platform is an all-in-one chromatographic platform that enables one-step analysis of lipid nanoparticle (LNP) formulations without sample pretreatment. It provides multiparameter insights into critical quality attributes, including encapsulation efficiency, nucleic acid integrity, particle size, lipid composition, nucleic acid–lipid adducts, and particle heterogeneity. Supporting multiple nucleic acid payloads, the dual-column valve-switching setup separates free and encapsulated components while enabling real-time characterization of LNPs. This innovation provides at-line, single-run readouts comparable to DLS, CE, and fluorescence assays, facilitating faster process monitoring and accurate quality control for nucleic acid–based therapeutics.
