Enhanced Monitoring of AAV Downstream Processes Using Liquid Chromatography Approaches

In-process control of AAV downstream processes (DSPs) ensures process efficiency, product quality, safety and consistency [1, 2, 3]. Using liquid chromatography (LC)-based methods such as size exclusion chromatography (SEC), cation exchange (CEX), and anion exchange (AEX) chromatography enables real-time monitoring of critical quality attributes.