Reproducibility of CIMac QA HR Columns

This application note showcases the reproducibility of quaternary amine (QA) based analytical monolithic columns, CIMac QA HR, across multiple batches, and demonstrates the applicability of CIMac QA HR for AAV empty – full analytics. When combined with an improved anion-exchange method, CIMac QA HR enables superior separation of empty and full AAV capsids. Additionally, this application note shows the maximum expected variation in elution profiles between columns at the extreme values of the acceptance criteria.